The first case of the novel coronavirus disease (COVID-19) was reported in Wuhan, China. The disease is caused by the Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2). On the African continent, the first case of the disease was confirmed in Egypt on the 14th of February 2020 [1]. Since then, the infection has spread to several African countries. As of February 2022, there have been more than 11.1 million total cases and over 247,000 mortalities recorded across Africa [2]. While vaccines are being rapidly rolled-out, non-pharmaceutical interventions like the closure of schools, travel restrictions, bans on public gatherings, and stay-at-home (lockdown) orders etc. are still being applied to varying degrees to manage the spread of the virus [3, 4]. These strategies are aimed at reducing the spread of the disease and protecting high-risk individuals and have varied across the continent in the degree of implementation and effectiveness based on differing country dynamics [5, 6].

African countries have some of the poorest health indices in the world. This is evident in the poor performance of their health systems and the ineffectiveness of their governance systems [7]. The continent also houses the largest percentage of the poorest people in the world and has had challenges in the progress towards achieving the Sustainable Development Goals [8]. These factors have an impact on the effectiveness of response efforts [9]. While Africa has not recorded high mortalities in comparison to Europe and South America, reported mortality has varied across the continent [10]. Cumulative confirmed deaths in Africa as of February 2022 was 239,838 for Africa and 1.63 Million and 1.22 million for Europe and America, respectively [11].

COVID-19 mortality across the globe has been shown to vary between countries. Non-pharmaceutical measures have been shown to be effective in curbing the transmission of the virus, and by extension reduce the mortalities associated with the pandemic, and the effect of this has varied by the level of stringency of these measures and the time of implementation [12, 13]. The mortality from COVID-19 has also varied due to other factors which include proportion of the elderly in the population, prevalence of co-morbidities like malignancies, diabetes, and social and systemic factors which include the level of health system preparedness, pandemic response time, the stringency of the non-pharmaceutical preventive measures, the effectiveness of governance [12, 14, 15].

These systemic factors especially the ones dealing with the quality of governance, pandemic preparedness, quality of healthcare, and level of human development have been shown to be highly relevant to the management of disease outbreaks and overall healthcare outcomes across the world [16–19]. For the convenience of nomenclature for this study these factors will all be collectively referred to as systemic factors.

Several indices have been developed to measure and assess some of these selected systemic factors, these include Government Response Stringency Index (SI), Human Development Index (HDI), Global Health Security Index (GHSI) and the Ibrahim Index of African Governance (IIAG). The Government Response Stringency Index (SI) was created by the Oxford research group as a composite measure of restriction policies made towards limiting the spread of the virus [20]. Two recent studies have revealed that lower degree of government stringency and slower response times were associated with more deaths from COVID-19 while the level of preparedness for epidemics had no effect on recorded deaths [21, 22].

The Global Health Security Index (GHSI) is a comprehensive assessment of capabilities in different countries to prevent and respond to the threats of infectious diseases, it was developed by the Nuclear Threat Initiative (NTI), Johns Hopkins Center for Health Security (JHU) and the Economist Intelligence Unit (EIU) [23]. A study of the GHSI of Organization for Economic Cooperation and Development OECD countries’ performance during the pandemic showed a discrepancy in GHSI rating of some countries and their actual performance as some countries with high GHSI scores did not fare well in managing the spread of COVID-19 [24].

The Human Development Index (HDI) was developed by the United Nations Development Program (UNDP) to measure the aspects of human development and standards of living in member states [25]. Studies conducted by Liu et al and Imtyaz et al demonstrated a positive relationship between high development index and higher death outcomes for COVID-19 [26, 27]. Considering the significance of governance and government capacity to appropriately responding to threats and matters, the Ibrahim Index of African Governance (IIAG) is a useful metric to consider in understanding how effective African governments are in in this regard [28]. The Mo Ibrahim foundation that is behind the index released a report on COVID-19 in Africa highlighting challenges with managing the pandemic on the continent which include poor access to healthcare, inadequate infrastructure, poor data practices and weak health systems [29].

There is a paucity of studies addressing the impact of these systemic factors on COVID death outcomes on the continent. This study aims to examine the association between systemic factors using indices like SI, GHSI, HDI, IIAG and the deaths from COVID-19 across African countries. Understanding how these selected systemic factors correlate with deaths due to COVID-19 can help inform decisions on system strengthening policies and governance across the continent in managing the pandemic and other infectious diseases that plague the continent. Understanding such associations can also help emphasize the importance of the state capacity, state response, and the quality of governance in effective epidemic response and management.

Data on TCDpermill, percentage of population aged 65 and older, SI, GHSI, IIAG and HDI data for 54 African countries are shown in Table 1.

The regression equation predicting TCDPerMill from all the independent variables is as follows: TCDPerMill = − 0.637 + 0.188 ×Age 56 Older + 0.016 ×SI + 0.002 ×GHSI + 0.005 ×IIAG − 0.0126 ×HDI

The Regression analysis (Figure 1) showed a statistically significant correlation between TCDPerMill and SI (coefficient = 0.024, p-value −0.000), and HDI relationship (coefficient = 3.303, p-value 0.000). No statistically significant relationship (coefficient = 0.007, p-value 0.537) was also found between TCDPerMill and GHSI (coefficient = 0.007, p-value 0.537), and IIAG (coefficient = 0.012, p-value 0.094).

Multiple linear regression was carried out to investigate whether SI, GHSI, HDI, IIAG and percentage of population aged above 65 could predict COVID-19 deaths in African countries. The results (Table 2) of the regression showed that the model was a significant predictor of COVID-19 deaths (F [5, 28] = 7.586, p = 0.00001). SI was the only variables that was significant in the model. Based on the model SI yields a 0.46 increase in TCDperMillion for every unit increase while controlling for the other variables and the covariate (Age65Older).

This study provides insight into factors affecting recorded deaths attributed COVID-19 across Africa and helps to further our understanding of how governance and health indices are associated with the recorded mortalities from the COVID-19 pandemic. Statistically significant associations were not found between the GHSI, IIAG, and deaths from COVID-19 which is similar to results obtained from a study conducted by Hooper that showed that the GHSI had no effects on COVID-19 deaths [21]. However, there was a positive association between deaths from COVID-19, SI and HDI. The GHSI is known as a tool that shows promise in giving insights into levels of biosafety and levels of systems preparedness for countries, but they are encouraged to look beyond it for mitigating factors for impact of pandemics, as this study and another conducted by Hooper have shown how it has no effect on the death outcomes for COVID-19 [21, 30]. The GHSI has been criticized for not incorporating the social and political features that have significant effect on public health outcomes across different countries, hence this is why it has not performed well in aligning with performance of different countries in managing COVID-19 [31].

Some of these results can be explained by the fact that we used total deaths as opposed to weekly averages for this study and the possibility that countries that had higher mortalities implemented stricter or more stringent measures to control the pandemic. The positive association seen between HDI and COVID-19 deaths is underlined by the percentage of the population aged above 65 being higher in countries with higher levels of HDI, because these countries have higher life expectancy because of better healthcare and living conditions [32]. Also, since these countries have higher indices of SI and IIAG too, and COVID-19 is more fatal in individuals above the age of 65, the positive association can be explained by the fact that there will be more deaths in these countries because of their higher population of persons above 65, and older people also constitute a significant percentage of those with co-morbidities [33, 34]. This is consistent with results from a study conducted by Liu et al which revealed a positive association between COVID-19 deaths and HDI in Italy, and in another study by Imtyaz et al. that revealed that European countries were recording higher COVID-19 deaths due to higher percentage of elderly people compared to other countries [26, 27].

However, the impact of HDI disappeared when we controlled for variables in a multiple regression with just Stringency Index and percentage of population aged 65 and above showing significance. This disappearance of effect could be explained by the fact that countries with higher HDIs have larger percentages of the population above 65 and controlling for this variable removes that effect. As shown earlier that there is a linear relationship between HDI and COVID-19 deaths, this effect can then be explained by the percentage of population aged above 65 in each country. This also shows that the strongest factors related to outcomes of death in Africa are SI and percentage of the population aged above 65.