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<article article-type="methods-article" dtd-version="2.3" xml:lang="EN" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Int. J. Public Health</journal-id>
<journal-title>International Journal of Public Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Int. J. Public Health</abbrev-journal-title>
<issn pub-type="epub">1661-8564</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">1608480</article-id>
<article-id pub-id-type="doi">10.3389/ijph.2025.1608480</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Public Health Archive</subject>
<subj-group>
<subject>Hints and Kinks</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>A Custom Keyword Tool for Improving the Quality of Social Media Monitoring on Vaccine Safety: A Proof of Concept</article-title>
<alt-title alt-title-type="left-running-head">Bucci et al.</alt-title>
<alt-title alt-title-type="right-running-head">Custom Keyword Tool for Social Media</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes" equal-contrib="yes">
<name>
<surname>Bucci</surname>
<given-names>Lucie Marisa</given-names>
</name>
<xref ref-type="aff" rid="aff1">
<sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001">&#x2a;</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>&#x2020;</sup>
</xref>
<uri xlink:href="https://loop.frontiersin.org/people/2285288/overview"/>
</contrib>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Lamprianou</surname>
<given-names>Smaragda</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>&#x2020;</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Gesualdo</surname>
<given-names>Francesco</given-names>
</name>
<xref ref-type="aff" rid="aff3">
<sup>3</sup>
</xref>
<xref ref-type="author-notes" rid="fn001">
<sup>&#x2020;</sup>
</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes">
<name>
<surname>Pal</surname>
<given-names>Shanthi</given-names>
</name>
<xref ref-type="aff" rid="aff2">
<sup>2</sup>
</xref>
<xref ref-type="author-notes" rid="fn002">
<sup>&#x2021;</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff1">
<sup>1</sup>
<institution>Bucci-Hepworth Health Services</institution>, <addr-line>Pincourt</addr-line>, <addr-line>QC</addr-line>, <country>Canada</country>
</aff>
<aff id="aff2">
<sup>2</sup>
<institution>World Health Organization</institution>, <addr-line>Geneva</addr-line>, <country>Switzerland</country>
</aff>
<aff id="aff3">
<sup>3</sup>
<institution>Department of Translational Research and New Technologies in Medicine and Surgery</institution>, <institution>University of Pisa</institution>, <addr-line>Pisa</addr-line>, <country>Italy</country>
</aff>
<author-notes>
<fn fn-type="edited-by">
<p>
<bold>Edited by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1261362/overview">L. Suzanne Suggs</ext-link>, University of Italian Switzerland, Switzerland</p>
</fn>
<fn fn-type="edited-by">
<p>
<bold>Reviewed by:</bold> <ext-link ext-link-type="uri" xlink:href="https://loop.frontiersin.org/people/1311864/overview">Dian Hu</ext-link>, University of Texas Health Science Center at Houston, United States</p>
<p>One reviewer who chose to remain anonymous</p>
</fn>
<corresp id="c001">&#x2a;Correspondence: Lucie Marisa Bucci, <email>lmbucci@bhhealthservices.com</email>
</corresp>
<fn fn-type="equal" id="fn001">
<label>
<sup>&#x2020;</sup>
</label>
<p>These authors have contributed equally to this work and share senior authorship</p>
</fn>
<fn fn-type="equal" id="fn002">
<label>
<sup>&#x2021;</sup>
</label>
<p>These authors share last authorship</p>
</fn>
</author-notes>
<pub-date pub-type="epub">
<day>21</day>
<month>08</month>
<year>2025</year>
</pub-date>
<pub-date pub-type="collection">
<year>2025</year>
</pub-date>
<volume>70</volume>
<elocation-id>1608480</elocation-id>
<history>
<date date-type="received">
<day>03</day>
<month>03</month>
<year>2025</year>
</date>
<date date-type="accepted">
<day>28</day>
<month>07</month>
<year>2025</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright &#xa9; 2025 Bucci, Lamprianou, Gesualdo and Pal.</copyright-statement>
<copyright-year>2025</copyright-year>
<copyright-holder>Bucci, Lamprianou, Gesualdo and Pal</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p>
</license>
</permissions>
<kwd-group>
<kwd>misinformation related to health</kwd>
<kwd>social media monitoring</kwd>
<kwd>vaccine safety</kwd>
<kwd>vaccine acceptance</kwd>
<kwd>vaccine hesitancy</kwd>
</kwd-group>
<counts>
<page-count count="6"/>
</counts>
</article-meta>
</front>
<body>
<sec id="s1">
<title>Background</title>
<p>Social media monitoring is one of several ways for health authorities to capture specific insights into population perceptions about vaccine safety [<xref ref-type="bibr" rid="B1">1</xref>]. Commercial and open-source tools are helpful for gathering data on socio-cultural, religious, and political trends, but also for detecting what is being said about vaccine safety and why populations are delaying or refusing vaccination [<xref ref-type="bibr" rid="B2">2</xref>]. Monitoring and tracking digital forums for target audiences and influencers and identifying misinformation provides additional understanding. However, despite the clear need, public health authorities globally are severely constrained in their capacity to effectively address the overwhelming volume and complexity of misinformation [<xref ref-type="bibr" rid="B3">3</xref>]. To complicate matters, international, national, and corporate infodemic management policies are imposing information users to change the way they share information online and on social media platforms. Recent examples of how information users are adapting include the use of memes and increasing the amount and speed of information disseminated between platforms. This rapid evolution of misinformation tactics and limited public health resources including insufficient staffing, and a lack of specialized digital capacity within many public health authorities, renders comprehensive oversight incredibly challenging. As digital information environments become more complex, existing tools for social media monitoring need to adapt to meet the needs of public health authorities that may not have the resources to undertake comprehensive social media listening [<xref ref-type="bibr" rid="B4">4</xref>]. For health authorities to truly benefit from better quality social media intelligence, innovations must be developed that are not only required but also accessible, adaptable and feasible to implement [<xref ref-type="bibr" rid="B5">5</xref>].</p>
<p>The Vaccine Safety Net (VSN), the World Health Organization&#x2019;s (WHO) global network that facilitates access to trustworthy, science-based vaccine safety information, identified this challenge as an opportunity to contribute to a rapidly expanding area. The VSN consists of member websites seeking to achieve more effective ways for communicating through digital and social media analytics research [<xref ref-type="bibr" rid="B6">6</xref>]. The latter involves identifying high impact vaccine safety related issues on social media for predicting and pre-bunking misinformation, developing and testing social media messages, as well as assessing their relevance and impact using a commercial platform with a social listening tool. Leveraging the VSN&#x2019;s expertise in social medial listening, we developed and tested a custom keyword filter designed for adaptable global implementation by public health authorities. This filter aims to address the significant challenge posed by the sheer volume and evolving nature of misinformation, which often overwhelm existing commercial and online generic filters and their ability to provide precise results. For example, many generic keyword filters rely on estimations and are capable of over-filtering (or under-filtering) valuable social media content and fail to capture relevant information. Social media content is highly contextual and generic keyword filters do not interpret the nuances of language (e.g., comedy, sarcasm, anger, etc.)</p>
</sec>
<sec id="s2">
<title>Objective</title>
<p>We sought to understand how to optimize social media searches on vaccine safety using a custom keyword filter for better quality search results. A proof-of-concept project whereby a custom keyword filter was designed using Kim et al.&#x2019;s [<xref ref-type="bibr" rid="B7">7</xref>] conceptual framework and tested using a commercial social listening platform and open source artificial intelligence (AI) tools with the intent of analyzing the quantity of irrelevant relevant mentions retrieved from vaccine safety searches on X<sup>&#xae;</sup> in Canada, United States, Italy and United Kingdom.</p>
<p>Unfiltered keywords can yield large amount of irrelevant data [<xref ref-type="bibr" rid="B8">8</xref>]. Therefore, custom keyword filters are meaningful methods for improving digital and social media monitoring practices in response to constantly evolving information environments. For additional accuracy, we chose to first create and test a keyword filter with vaccine -related keywords. A vaccine safety keyword filter was subsequently created and tested to distill the information. We added artificial intelligence (AI) derived keywords to the filter, which expanded the social media datasets.</p>
</sec>
<sec sec-type="methods" id="s3">
<title>Methods</title>
<p>The custom keyword filter involves three steps: 1) frequency screening; 2) sampling; and 3) search implementation.</p>
<sec id="s3-1">
<title>Frequency Screening</title>
<p>A list of candidate vaccine and vaccine safety keywords were pooled in collaboration with VSN members from Canada, Italy, United States and United Kingdom. Candidate keywords were selected considering native language of targeted countries, media reports, published literature and epidemiological events. The list of candidate keywords was applied to a six [<xref ref-type="bibr" rid="B6">6</xref>] month retrospective scan of X<sup>&#xae;</sup> conversations between January and June 2023 using a commercial social media monitoring platform. We tracked keywords that peaked on X<sup>&#xae;</sup> and developed a history of trending candidate keywords for this period. We used this dataset to identify the frequency of candidate keywords. Candidate keywords that had less than 30% of mentions per month were discarded from the keyword list. This frequency threshold was selected through team consensus for this proof of concept. This initial triage was used to identify vaccine and vaccine safety keywords used more regularly in X<sup>&#xae;</sup> conversations.</p>
<p>A data analyst was enlisted to assist with AI keyword identification. Additional vaccine and vaccine safety-related keywords were extracted from the original dataset using Bidirectional Encoder Representations from Transformers (BERT) and Generative Pre-trained Transformer 3 (GPT-3).</p>
</sec>
<sec id="s3-2">
<title>Sampling</title>
<p>The remaining candidate keywords were then screened for relevance. To do this, a real time dataset of X<sup>&#xae;</sup> keyword mentions of up to one [<xref ref-type="bibr" rid="B1">1</xref>] week was generated. We sampled two hundred (200) mentions for each candidate keyword, including reposts using a commercial sample operator. Three team members, experts in vaccination and vaccine safety, reviewed each sample to determine relevance. We assessed the relevance of keywords by classifying their sensitivity and specificity to &#x201c;vaccine-related&#x201d; and then &#x201c;vaccine safety-related&#x201d; words. Keywords were considered relevant if they were used in the context of vaccination conversations or was implicit in meaning.</p>
<p>Keywords that returned no relevance were removed from the list but added to a &#x201c;negative keyword list&#x201d; for prospective Boolean searches. Duplicate posts within each keyword dataset were also removed. Other content in posts such as emojis, hashtags and usernames were not considered relevant. Links to websites, if included in posts, were used to clarify context of post. Replies were also excluded. Lastly, common words known as &#x201c;stop-words&#x201d; (e.g., the, she, he, it, are, etc.) were excluded.</p>
</sec>
<sec id="s3-3">
<title>Search Implementation</title>
<p>Keywords determined to be highly relevant were not used in a new prospective search on X<sup>&#xae;</sup> to evaluate the quality of their search results. This final step was not part of the scope of this proof of concept.</p>
</sec>
</sec>
<sec sec-type="results" id="s4">
<title>Results</title>
<p>Thirty (30) vaccine and vaccine safety-related keywords were extracted for each country (see <xref ref-type="fig" rid="F1">Figures 1</xref>, <xref ref-type="fig" rid="F2">2</xref>) using manual and AI methods. Vaccine-related keywords were used in three thousand one hundred and seventy-eight (3178) posts. While vaccine safety-related keywords were used in eight-hundred and sixty-nine (869) posts (see <xref ref-type="table" rid="T1">Table 1</xref>). Bert and GPT identified additional keywords including combined terms not previously identified. Themes extracted and analysed from vaccine safety-related mentions include public skepticism about vaccine safety, particularly COVID-19 vaccines, polarization between vaccination perspectives, concerns about misinformation, mistrust in government, influencers, and pharmaceutical companies.</p>
<fig id="F1" position="float">
<label>FIGURE 1</label>
<caption>
<p>Keyword visualization: Vaccine safety related posts (Canada &#x26; United States (top), United Kingdom &#x26; Italy (bottom)) (Switzerland, 2024).</p>
</caption>
<graphic xlink:href="ijph-70-1608480-g001.tif">
<alt-text content-type="machine-generated">Four bar charts titled &#x22;Word frequency safety related&#x22; for Canada, the United States, the United Kingdom, and Italy display the relative frequency of words such as &#x22;vaccine,&#x22; &#x22;covid,&#x22; &#x22;pfizer,&#x22; and &#x22;mrna,&#x22; among others. Each chart lists words along the y-axis, with frequency per post on the x-axis, indicating the most common terms related to safety discussions in each country.</alt-text>
</graphic>
</fig>
<fig id="F2" position="float">
<label>FIGURE 2</label>
<caption>
<p>Keyword visualization: Vaccine related but not safety related posts (Canada &#x26; United States (top), United Kingdom &#x26; Italy (bottom)) (Switzerland, 2024).</p>
</caption>
<graphic xlink:href="ijph-70-1608480-g002.tif">
<alt-text content-type="machine-generated">Four bar charts display word frequencies in posts about vaccines, excluding safety-related terms, from Canada, the US, the UK, and Italy. Common words include &#x22;vaccine,&#x22; &#x22;covid,&#x22; and &#x22;people,&#x22; with variations among the countries. Each chart shows words on the y-axis  and frequency per post on the X-axis.</alt-text>
</graphic>
</fig>
<table-wrap id="T1" position="float">
<label>TABLE 1</label>
<caption>
<p>Number of posts per country (Switzerland, 2024).</p>
</caption>
<table>
<thead valign="top">
<tr>
<th align="left">Country</th>
<th align="center">Filter</th>
<th align="center">&#x23; Vaccine related</th>
<th align="center">&#x23; Vaccine safety related</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left">CAN</td>
<td align="left">COVID-19 vaccine</td>
<td align="center">199</td>
<td align="center">37</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">Coronavirus</td>
<td align="center">53</td>
<td align="center">13</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">COVID vaccines</td>
<td align="center">193</td>
<td align="center">41</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">Side effects</td>
<td align="center">92</td>
<td align="center">76</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">AstraZeneca</td>
<td align="center">101</td>
<td align="center">58</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">Pfizer</td>
<td align="center">142</td>
<td align="center">63</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">Pandemic</td>
<td align="center">4</td>
<td align="center">0</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">Plandemic</td>
<td align="center">32</td>
<td align="center">4</td>
</tr>
<tr>
<td align="left">CAN</td>
<td align="left">Total</td>
<td align="center">816</td>
<td align="center">292</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">COVID</td>
<td align="center">13</td>
<td align="center">2</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">COVID-19</td>
<td align="center">45</td>
<td align="center">4</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">Coronavirus</td>
<td align="center">46</td>
<td align="center">6</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">Vaccine</td>
<td align="center">188</td>
<td align="center">42</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">Vax</td>
<td align="center">182</td>
<td align="center">28</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">Vaxx</td>
<td align="center">182</td>
<td align="center">25</td>
</tr>
<tr>
<td align="left">USA</td>
<td align="left">Total</td>
<td align="center">656</td>
<td align="center">107</td>
</tr>
<tr>
<td align="left">UK</td>
<td align="left">Vaccine</td>
<td align="center">117</td>
<td align="center">45</td>
</tr>
<tr>
<td align="left">UK</td>
<td align="left">Vaccine</td>
<td align="center">39</td>
<td align="center">2</td>
</tr>
<tr>
<td align="left">UK</td>
<td align="left">COVID</td>
<td align="center">29</td>
<td align="center">14</td>
</tr>
<tr>
<td align="left">UK</td>
<td align="left">Jabs</td>
<td align="center">60</td>
<td align="center">12</td>
</tr>
<tr>
<td align="left">UK</td>
<td align="left">Coronavirus</td>
<td align="center">18</td>
<td align="center">5</td>
</tr>
<tr>
<td align="left">UK</td>
<td align="left">Total</td>
<td align="center">263</td>
<td align="center">78</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccino</td>
<td align="center">200</td>
<td align="center">72</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccini</td>
<td align="center">194</td>
<td align="center">76</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccinato</td>
<td align="center">184</td>
<td align="center">30</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccinata</td>
<td align="center">114</td>
<td align="center">24</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccinati</td>
<td align="center">190</td>
<td align="center">57</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccinate</td>
<td align="center">139</td>
<td align="center">36</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccinare</td>
<td align="center">196</td>
<td align="center">17</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Vaccinazion</td>
<td align="center">200</td>
<td align="center">69</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Immunizzazione</td>
<td align="center">44</td>
<td align="center">10</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Pfizer</td>
<td align="center">91</td>
<td align="center">36</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">COVID19</td>
<td align="center">25</td>
<td align="center">9</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">COVID-19</td>
<td align="center">66</td>
<td align="center">28</td>
</tr>
<tr>
<td align="left">IT</td>
<td align="left">Total</td>
<td align="center">1443</td>
<td align="center">392</td>
</tr>
</tbody>
</table>
</table-wrap>
<sec id="s4-1">
<title>Conclusion</title>
<p>Our objective was to develop a custom keyword filter for producing better quality social media intelligence for public health authorities to easily use and be versatile in their vaccine safety communication strategies. We found the development of a custom keyword filter that uses both manual and AI as methods for extracting social media mentions and performing content analysis about vaccine and vaccine safety-related posts yielded quality data. The strategy for our proof-of-concept study used a commercial platform for testing and keyword refinement. We anticipate that custom keyword filters may be used with other commercial and freely available keyword filters for more precise results. This is an advantage over using commercial or online filters alone. That said, keyword filter refinement is a time-consuming process as well as data analysis and interpretation. Despite these shortcomings, social media monitoring innovations are needed to keep with changing information environments. While we did not test the keyword filter for sensitivity, we found the filter to meet our expectations for specificity. New tools need to focus on improving the relevance of outputs. AI offers other avenues for filtering candidate keywords but we are still learning about its limitations. Our proof-of-concept project contributes to a rapidly evolving area and provides new insights on how public health can use adaptable keyword filter tools, in addition to commercial tools, to improve their capacity to respond to online misinformation.</p>
</sec>
</sec>
</body>
<back>
<sec sec-type="author-contributions" id="s5">
<title>Author Contributions</title>
<p>LB, SL and FG wrote the manuscript. All authors contributed to the article and approved the submitted version.</p>
</sec>
<sec sec-type="funding-information" id="s6">
<title>Funding</title>
<p>The author(s) declare that no financial support was received for the research and/or publication of this article.</p>
</sec>
<sec sec-type="COI-statement" id="s7">
<title>Conflict of Interest</title>
<p>The authors declare that they do not have any conflicts of interest.</p>
</sec>
<sec sec-type="ai-statement" id="s8">
<title>Generative AI Statement</title>
<p>The author(s) declare that no Generative AI was used in the creation of this manuscript.</p>
</sec>
<ack>
<p>We want to thank Alberto E. Tozzi, Ian Roe, Craig Thompson, Charlotte Moser, and the VSN research working group, Kristen De Graaf, Eve Dub&#xe9;, Tina Purnat, Elisabeth Wilhelm, for their contribution to the development of the implementation and evaluation framework, and to Isabelle Sahinovic, Tala Ghalayini, Brian Yau, and C&#xe9;cile Mac&#xe9; for their support. We also want to thank Susan Cheatham for her work on keyword extraction and analysis.</p>
</ack>
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